| Passage | 1-16 | 0-8 | Bishopstown | Passage | 06/03/2022 | 11:00 |
| Whitechurch | 2-6 | 0-7 | Brian Dillons | White Church | 06/03/2022 | 11:30 |
| St Vincents | 1-11 | 3-9 | Whites Cross | Pairc Uinsinn | 06/03/2022 | 14:00 |
| Delanys | 2-10 | 1-7 | St Michaels | Páirc Dubhslanaigh | 06/03/2022 | 15:00 |
| Nemo Rangers | 1-8 | 1-12 | Douglas | Trabeg | 06/03/2022 | 15:00 |
| Douglas | 0-17 | 1-4 | Whitechurch | Douglas | 17/03/2022 | 11:30 |
| St Michaels | 0-6 | 2-7 | Nemo Rangers | Trabeg | 19/03/2022 | 15:00 |
| Bishopstown | 3-5 | 1-9 | Delanys | Bishopstown | 20/03/2022 | 11:30 |
| Whites Cross | 1-6 | 1-15 | Passage | Passage | 20/03/2022 | 11:30 |
| Brian Dillons | 1-9 | 1-8 | St Vincents | Pairc Na Brian Diolunaigh | 22/03/2022 | 19:30 |
| Brian Dillons | 1-3 | 2-14 | Douglas | Pairc Na Brian Diolunaigh | 01/04/2022 | 19:30 |
| Nemo Rangers | 5-11 | 0-5 | Bishopstown | Trabeg | 03/04/2022 | 11:00 |
| Delanys | 3-8 | 1-15 | Whites Cross | Páirc Dubhslanaigh | 03/04/2022 | 11:30 |
| St Vincents | 2-4 | 2-19 | Passage | Pairc Uinsinn | 05/04/2022 | 19:00 |
| Whitechurch | 1-5 | 4-13 | St Michaels | White Church | 12/04/2022 | 19:00 |
| Douglas | 2-24 | 1-4 | St Vincents | Douglas | 16/04/2022 | 17:00 |
| Bishopstown | 0-10 | 1-6 | Whitechurch | Bishopstown | 16/04/2022 | 19:00 |
| Passage | - | - | Delanys | Passage | 17/04/2022 | 11:30 |
| Whites Cross | 3-7 | 3-7 | Nemo Rangers | Trabeg | 17/04/2022 | 11:30 |
| St Michaels | 0-23 | 0-7 | Brian Dillons | Pairc Mhichil | 19/04/2022 | 19:00 |
| Nemo Rangers | 0-12 | 0-14 | Passage | Trabeg | 26/04/2022 | 19:15 |
| Douglas | 2-14 | 1-10 | St Michaels | Douglas | 30/04/2022 | 17:30 |
| Whitechurch | 1-8 | 1-8 | Whites Cross | White Church | 30/04/2022 | 19:30 |
| Brian Dillons | - | - | Bishopstown | Pairc Na Brian Diolunaigh | 01/05/2022 | 11:30 |
| St Vincents | 0-9 | 6-15 | Delanys | Pairc Uinsinn | 03/05/2022 | 19:00 |
| Passage | 0-9 | 1-3 | Whitechurch | Passage | 14/05/2022 | 19:30 |
| Whites Cross | 0-11 | 1-7 | Brian Dillons | Pairc Na Brian Diolunaigh | 14/05/2022 | 19:30 |
| Bishopstown | 3-14 | 2-13 | Douglas | Bishopstown | 15/05/2022 | 11:30 |
| Delanys | 2-11 | 2-15 | Nemo Rangers | Páirc Dubhslanaigh | 15/05/2022 | 16:00 |
| St Michaels | 3-14 | 0-4 | St Vincents | Pairc Mhichil | 17/05/2022 | 19:25 |
| Brian Dillons | - | - | Passage | Pairc Na Brian Diolunaigh | 27/05/2022 | 19:30 |
| Whitechurch | 0-15 | 5-9 | Delanys | White Church | 28/05/2022 | 19:30 |
| Douglas | 0-16 | 0-8 | Whites Cross | Douglas | 29/05/2022 | 11:30 |
| St Michaels | 4-17 | 2-5 | Bishopstown | Pairc Mhichil | 29/05/2022 | 11:30 |
| St Vincents | - | - | Nemo Rangers | Pairc Uinsinn | 29/05/2022 | 11:30 |
| Whites Cross | 0-6 | 2-21 | St Michaels | Pairc Mhichil | 08/06/2022 | 19:30 |
| Bishopstown | 1-16 | 1-6 | St Vincents | Bishopstown | 09/06/2022 | 19:30 |
| Douglas | 0-13 | 0-6 | Delanys | Douglas | 12/06/2022 | 15:00 |
| Nemo Rangers | 1-9 | 0-11 | Whitechurch | Trabeg | 13/06/2022 | 19:30 |
| Nemo Rangers | 3-13 | 0-5 | Whitechurch | Trabeg | 13/06/2022 | 19:30 |
| St Michaels | 1-10 | 0-8 | Passage | Pairc Mhichil | 20/06/2022 | 19:30 |
| Bishopstown | - | - | Whites Cross | Bishopstown | 25/06/2022 | 19:00 |
| Whitechurch | - | - | St Vincents | White Church | 25/06/2022 | 19:30 |
| Passage | 2-4 | 4-17 | Douglas | Ballinlough | 07/07/2022 | 19:00 |
| | - | - | | | | 01:00 |
